Another interesting overlap is the angiogenesis pathway shared exclusively between Alz and T1D, especially if interpreted in relation to blood brain barrier dysfunction due to increased vascular permeability induced by hyperglycemia [29].
Our study demonstrates that intracranial hypotension can induce higher frequency of audiovestibular dysfunction, which may be attributed to both irritation or dysfunction of the peripheral labyrinth or vestibulocochlear nerve, and brainstem or cerebellar dysfunction due to brain sagging.
We hypothesized that ACUP on GB 34 has an effect on brain areas that are known to show dysfunction due to nigral dopamine depletion.
The core symptom of VaD is progressive cognitive dysfunction due to cumulative regional brain tissue injury associated with localized cerebrovascular disruptions (microinfarcts or "mini strokes") [ 4].
Based on the literature, we hypothesize that acupuncture stimulation on GB 34 has an effect on brain areas that are known to show dysfunction due to nigral dopamine depletion: the prefrontal cortex [ 37], precentral gyrus [ 38], thalamus [ 39], globus pallidus [ 40], caudate [ 41], and putamen [ 38].
From the earliest days of nineteenth-century aphasiology, language deficits due to focal brain lesions have been attributed to two basic mechanisms: local cortical dysfunction at the lesion site, and remote cortical dysfunction due to disruption of information transfer along pathways between connected brain regions (Wernicke, 1874; Geschwind, 1965 a, b ).
Change in DA relative to other monoamines suggests a relationship between CNS dysfunction due to lead and DA metabolism in the brain.
Focal brain lesions are assumed to produce language deficits by two basic mechanisms: local cortical dysfunction at the lesion site, and remote cortical dysfunction due to disruption of the transfer and integration of information between connected brain regions.
Shang, L. et al. beta-cell dysfunction due to increased ER stress in a stem cell model of Wolfram syndrome.
