In this a priori designed subgroup analysis of the MENDS study, septic patients receiving DEX had more days free of brain dysfunction and MV and were less likely to die than those that received a LZ-based sedation regimen.
These changes are independent of brain dysfunction and appear to be related to the expression of mutant htt in peripheral tissues (van der Burg et al., 2009).
Sepsis-associated delirium is the most common brain dysfunction and it can be found in up to 70%% of septic patients [38, 39].
Sepsis-associated delirium is the most common brain dysfunction and it can be found in up to 70%% of septic patients [ 38, 39].
Also, new biomarkers associated with brain dysfunction and cognitive impairment are still recognized and need to be studied to determine their relation with delirium.
A positive relationship between consumption of food with abundant phenolics and low incidence of degenerative diseases, including cancer, heart disease, inflammation, arthritis, brain dysfunction and cataracts, has been confirmed [1].
Investigations on the relationship between sepsis, brain dysfunction, and cerebral perfusion are methodologically very difficult to perform.
In this subgroup analysis, septic patients receiving dexmedetomidine had more days free of brain dysfunction and mechanical ventilation and were less likely to die than those that received a lorazepam-based sedation regimen.
Although it seems evident that activation of the immune system can induce acute brain dysfunction and that sepsis, therefore, is a major risk factor for delirium, most studies are hampered by the fact that sepsis encompasses a variety of different sources and states of infection and do not focus on the immediate and acute neurological impact of specific infections in critical care settings.
