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Finally, although it is clear that gonadal hormones have dramatic permanent effects on the brain during perinatal development, even after puberty and in adulthood gonadal steroids can alter neuronal structure and, perhaps as a corollary to this, have permanent effects on reproductive function.
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Although the brain may be most sensitive to gonadal hormones or exogenous chemical factors during perinatal development, such sensitivity does not appear limited to this period.
Nutrient deficiency during perinatal development is associated with an increased risk to develop obesity, diabetes and hypertension in the adulthood.
Single cell RNA profiling identifies a diversity of pulmonary cells during perinatal development, and provides access to the genes, processes, and cell cell interactions regulating pulmonary structure and function at birth.
Malrotation in children is due to either an incomplete or non-rotation of the foetal mid-gut during perinatal development.
Notably, exposure to nutrient restriction during perinatal development results in offspring which are hyperphagic and exhibit enhanced preference for high-fat food [11], [12], [13], [14].
This process resembles the maturation of the mammalian intestine during perinatal development when plasma T3 level is high [ 111, 112].
Using IRC mice, Miyawaki et al. (2007) administered 1 or 10 µg BPA/L drinking water during perinatal development.
10.7554/eLife.05151.006 Figure 2. Nf1 inactivation leads to increased proliferation of intermediate glial precursors and subsequent glial/neuronal defects during perinatal development.
Environmental factors during perinatal development may influence developmental plasticity and disease susceptibility via alterations to the epigenome.
Current techniques are inadequate for assessing functional capability during perinatal development, and there is a need for improved measures.
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