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A recently identified class of master regulatory molecules, known as microRNAs (miRNAs), have the potential to assist in the countless regulatory mechanisms that occur in the brain during neuronal development and function.
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Brain-derived neurotrophic factor (Bdnf) plays a critical role during neuronal development and is therefore a prime candidate to modulate neuronal signaling in adult offspring of rat dams that were stressed during gestation.
Hence, the overexpression of miR-132 could potentially mediate its effects during neuronal development and by altering gene expression in multiple brain regions.
Dyrk1A has been shown to have a highly dynamic expression pattern throughout mouse brain development suggestive of a key role in regulating the multiple events that occur during neuronal development [85].
Deciphering the complex gene regulatory networks that act during neuronal development is essential to our understanding of the relationship between genes, the brain, and behavior.
Spontaneous bursts play a fundamental role during neuronal development [8].
These factors were also induced during neuronal development and function in neuronal migration in vivo.
These findings reveal an unexpected role for growth cone filopodia during layer formation and highlight the importance of assessing subcellular dynamics in relation to long-term neuronal development during brain wiring.
Exposure of the brain to environmental agents during critical periods of neuronal development is considered a key factor underlying many neurologic disorders.
Additionally, gaining an understanding of how brain circuits develop helps unravel those instances when neuronal development goes awry, such as during developmental disorders and diseases.
These activity-dependent changes occur during critical windows of neuronal development as well as in the adult brain, enabling the animal to best perform in a given environment.
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CEO of Professional Science Editing for Scientists @ prosciediting.com