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Although 5αR2 has been reported to be highly expressed in the brain during early developmental stages, little is currently known on its anatomical and cellular distribution in the adult brain.
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Since the morphants displayed altered phenotypes mainly in the brain region during early developmental stages (24 hpf), we performed in situ hybridization to analyze the expression pattern of several marker genes involved in neural patterning of the brain.
Further impairments may emerge later in life as a result of brain injury during early developmental stages.
In addition, it is well-documented that the phosphorylation status of tau is developmentally regulated, with higher phosphorylation levels being present during early developmental stages of the brain compared to the mature, adult brain [ 16, 19, 22].
Many forms of neuroplasticity are at their maximum during early developmental stages that are exclusive to the developing brain.
GAD25 is abundant during early developmental stages but is also present in the adult brain in regions that undergo continuous synaptic rearrangements [23], [24].
Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development.
In aquatic vertebrates, bioaccumulation was assessed during early developmental stages.
This result suggests that maternal Sec24D plays a minor role during early developmental stages.
We have previously described the expression patterns of X. laevis MT3-MMP and TIMP-3 during early developmental stages.
In contrast, fC declines rapidly with age during early developmental stages, thus suggesting that while hmC is a stable epigenetic mark, fC is more likely an intermediate of active DNA demethylation during early brain development.
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