Sentence examples for brain distribution of the from inspiring English sources

The regional brain distribution of the radiolabeled [18F]1 was studied in CD-1 male mice.

Conclusion: Our data suggest that the effect of the ABCG2 SNP on brain distribution of the dual ABCB1/ABCG2 substrate [11C]tariquidar was masked in the first PET scan by the functional compensation between ABCB1 and ABCG2 at the BBB.

To this end, 20 µl of liposomes containing 25 µg doxycycline were infused icv and the brain distribution of the drug was determined four days later by fruorescence microscopy of frozen sections.

Image acquisition can be started up to some hours after administration still representing the brain distribution of the radiopharmaceutical at the moment of injection allowing for experiments to be performed in ideal psychological conditions in a quiet environment outside of the camera gantry.

When the need for a novel radiotracer is established, we make use of the following principles to guide our development program: In-house analysis of tissue slices, cell cultures, and protein preparations is paramount to determine the density and regional brain distribution of the target, the change in target density or occupancy, and the binding affinities of lead candidate radiotracers.

Furthermore it makes only a relatively small contribution to the overall brain distribution of these GCs.

Single-group one-sample t-tests were used to analyze the whole-brain distribution of the DMN component in each group separately and the resulting t-maps were thresholded at p = 0.05 (Bonferroni corrected over the entire brain).

A deeper understanding of the brain distribution of cephalosporins may aid in the better use of these antibacterial agents for the prophylaxis and treatment of CNS infections.

APNPs administered via intranasal route facilitated the brain distribution of APZ incorporated with the AUC0 → 8 in rat brain approximately 2 times higher than that of APNPs administered via intravenous route.

We utilized a novel in vitro model of transient focal ischemia to analyze the brain distribution of neurosphere-derived cells (NCs) in the early 3 hours that follow transient occlusion of the medial cerebral artery (MCA).

Effect of pretreatment with tariquidar (15 mg/kg, administered 30 min before the start of the quinidine infusion) on the brain distribution of quinidine was assessed.