Thanks to Geschwind's vision, the anatomy of white matter connections derived from 19th century postmortem dissections was revisited in the living human brain and disconnection lesions to specific tracts were considered a valid mechanism for newly described syndromes (e.g., tactile agnosia; Geschwind and Kaplan 1962).
Released from cells along the CNS and body edge, SMED-WNT5 protein seems to restrict axonal growth and assist integration of new and existing neuronal networks, because RNAi against Smed-Wnt5 leads to the expansion of the brain and disconnections along the ventral nerve cords (Adell et al., 2009; Gurley et al., 2010).
Our results provide evidence for the functional disconnection of brain regions in MCI.
Previous studies have shown that loss of consciousness in UWS patients is associated with a variable degree of brain damage and physical disconnection of neural linkages57,58.
He could speak, and there was a dazed look to his eyes, a disconnection between brain and operation.
Furthermore, inducible ablation of GluRδ2 in the adult brain causes mismatching and disconnection of PF-PC synapses [19].
The case describes a rare and as yet unreported association between random, impulse-driven fire-setting behavior and damage to the brain and suggests a disconnection of frontal lobe structures as a possible pathogenic mechanism.
The locations of thalamus and the precuneus provided us with a novel idea that perhaps the damage which resulted by TBI was not only the focal lesion but also the disconnection of brain network.
Damage to the corpus callosum has been linked to a range of abnormal social behaviours 28 and may lead to disconnection between brain regions that integrate semantic knowledge (left hemisphere) with emotional meaning (right hemisphere), impacting on the ability to interpret paralinguistic information and situational context, a common feature in bvFTD.
It has been proposed that the gamma band activity is associated with short-distance synchronization whereas the beta band activity supports long-distance synchronization [ 15], implying that deficits in neural oscillations and synchronization might be accompanied with functional disconnection between brain areas as well as anatomical connectivity.
