Exact(12)
By tracing fiber pathways throughout the entire brain, diffusion tractography provides information that cannot be achieved by conventional anatomical MR imaging or histology.
Brain diffusion templates contain rich information about the microstructure of the brain, and are used as references in spatial normalization or in the development of brain atlases.
However, the widespread clinical application of GDNF has been hindered, in part, as a consequence of its heparin-binding domains and large molecular size limiting brain diffusion [6].
5, 6 Brain diffusion tensor imaging revealed involvement of the pyramidal tract, 7 which may extend to the spinal cord.
Connectivity matrices generated from 2 different mouse brain diffusion acquisitions were compared with each other to assess interstudy similarity (Supplementary Fig. 8).
Using whole brain diffusion tractography and graph theoretical analysis, McColgan, Seunarine et al. identify a specific role for highly connected rich club regions as a substrate for structural connectivity loss in Huntington's disease.
Similar(48)
In order to assess patterns of diffuse neurodegeneration in multiple sclerosis, we used novel post-mortem whole brain diffusion-weighted and structural MRI in combination with quantitative histology.
Brain diffusion-weighted magnetic resonance (MR) imaging showed acute ischemia within the right centrum semiovale, MR angiography demonstrated multiple stenotic segments both in anterior and posterior circulations particularly in the right arteria cerebri media (ACM) (Fig. 1a c).
Whole brain diffusion-weighted imaging was obtained using a multiple shot spin-echo technique (repetition time/echo time = 7075/62 msec, field of view 112 mm, 2-mm isotropic resolution, b values = 0, 800 sec/mm, 15 isotropically distributed gradients).
The combination of thalamic proton magnetic resonance spectroscopy (10 min acquisition duration) and brain diffusion-weighted imaging (2 min acquisition duration) may increase the diagnostic accuracy of the magnetic resonance scan.
Using these native clusters, mean pre- and postoperative FA, MD, λ ∥ and λT values were calculated by masking the corresponding whole-brain diffusion parameter images with the clusters.
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