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More restricted and specific expression patterns during brain development were observed for transcripts of LARGE, ARSA, GCNT2 and GALNT9.
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Within the first 48 h, severe defects in CNS development were observed in the Ecrg4a MO group including a brain ventricular hydrocephalus-like edema phenotype.
Cytopathic effects (CPE) development was observed.
The indispensable role of Rnd3 in mouse brain development was also observed in two recent studies 9, 10.
Brain development is at risk, UNICEF reported.
Whether m6A regulates mammalian brain development is unknown.
"Brain development is delicate in terms of its timing.
Impaired brain development is linked to oxidative stress because of the high lipid content of brains.
Preserved blood-brain barrier and attenuated brain edema were observed following simvastatin treatment.
Brain MRI abnormalities were observed in 4 (21%) patients, and myelitis was observed in one patient.
No specific brain MRI abnormalities were observed.
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