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The same factors are likely to be important for CPF effects on brain development in vivo.
Such investigations are needed to reveal whether PBDEs as a hazard identified in this study actually pose a risk for human brain development in vivo.
Studies of CPF effects on brain development in vivo indicate high susceptibility of these two transmitter systems, but with disparate patterns.
2, 3 Advances in magnetic resonance imaging (MRI) have enabled investigators to characterize premature infant brain development in vivo 4 in an effort to identify the alterations in brain development underlying the high incidence of significant disabilities.
Our findings are consonant with the increased role of cholinergic factors in the effects of CPF on later versus earlier stages of brain development in vivo (Whitney et al. 1995) and are further reinforced by the results for nicotine, which stimulates nicotinic acetylcholine receptors directly.
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Specifically we study the impact of noncoding RNAs, histone modifications, enhancer activity, and somatic mutations on typical and atypical brain development in human brain organoid culture and, whenever possible, in vivo.
THE LEARNING BRAIN Memory and Brain Development in Children.
We used module preservation analysis [ 40] to compare the identified modules with independent expression profiles from in vivo human brain development and in vitro neuronal differentiation of primary human neural progenitor cells (phNPCs) (Methods).
RORγtM supports thymocyte development in vivo.
Collectively, these data establish the requirement of RING tetramerization in APL development in vivo and arsenic response ex vivo.
Arlotta, P. et al. Neuronal subtype-specific genes that control corticospinal motor neuron development in vivo.
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