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Prolonged or repetitive pain occur during critical periods of brain development in preterm neonates [ 6].
Volpe (2009) argues that brain development in preterm infants is ultimately dependent on a combination of destructive and impaired maturational mechanisms.
There is a need for clear evidence of the relationship between early nutrient intake and brain development in preterm infants, so that improved nutrient regimens can be designed.
This is especially important for infants, as untreated or poorly treated procedural pain in early infancy can lead to altered pain responses [ 10, 11], and contribute to impaired brain development in preterm infants [ 12].
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THE LEARNING BRAIN Memory and Brain Development in Children.
"They are different in hormonal development, in brain development, in physiological development and in social development," they say.
Despite the extensive research into brain development after preterm birth, few studies have investigated its long-term effects on cortical thickness.
In terms of neurological outcome, brain development after extremely preterm birth is complex and poorly understood.
Support vector regression enabled quantitative estimation of birth gestational age in single subjects using only term equivalent resting state-functional MRI data, indicating that the present approach is sensitive to the degree of disruption of brain development associated with preterm birth (using gestational age as a surrogate for the extent of disruption).
Conversely, the mid late-third trimid late-thirdo representrimestertial window of positively influencing brain developmayt to improve preterm outcome alsotrepresentnatally acquired brain injury (Als et al. 2004; Guzzetta et al. 2011).
While this investigation confirms a strong allometric scaling relationship in the preterm brain, it suggests that this relationship is not a sensitive indicator of atypical cortical development in preterm infants or affected by clinical factors.
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