RTT is a progressive neurodevelopmental disorder involving a maturational arrest of brain development and synaptic proliferation (Amir et al. 1999; Johnston et al. 2001).
Jarid2 inhibits cyclin D1 transcription during heart and brain development and thereby controls cellular proliferation and differentiation in these organs during morphogenesis [ 10- 12].
We hypothesise that CEP63 is particularly important for brain development and might control the proliferation and migration of cells when those two events need to be highly coordinated.
Ni et al. [ 50] showed that the overexpression of IGFBP-1 impairs brain development and reduces glial cell proliferation in response to injury, in transgenic mice.
Interestingly, CDKL5 expression was inhibited by MYCN, a transcription factor that promotes cell proliferation during brain development and plays a relevant role in neuroblastoma biology.
They've found that different pesticides can have very different influences on cell proliferation, differentiation, and death during brain development, and all of these effects are dependent upon dose and time of exposure during development.
The mTOR pathway acts as key regulator of cell size and growth control, proliferation, differentiation and survival during brain development, and increasing evidence supports the role of the TOR pathway in a wide variety of neurological disorders including both MCD and brain tumors [ 1, 23, 26, 96].
Herein, we show that CDKL5 expression affects neuronal proliferation and differentiation, two processes closely related during brain development, and that CDKL5 is negatively regulated by MYCN, a key player in neuronal development.
The transcription factor Stat3 is known to strongly influence proliferation, survival, growth and differentiation of neuronal cells during brain development and in mature brain after injury.
"You can tie it to brain development and dawning humanity.
