Fascin insufficiency or dysregulation might underlie disorders of brain development and plasticity, resulting in intellectual disability (Kraft et al., 2006).
Low birth weight might be responsible for some impairment in brain development, and could result in lower intellectual performance.
Despite the clear involvement of CDKL5 mutations in intellectual disability, the function of this protein during brain development and the molecular mechanisms involved in its regulation are still unknown.
In this condition brain development and function are severely affected, with microcephaly and number of other CNS symptoms/signs, including developmental delay, intellectual disability, spasticity, ataxia, dysarthria and myoclonus [ 80, 81].
"You can tie it to brain development and dawning humanity.
However, RT in childhood may also have severe side effects including impaired brain maturation and intellectual development.
It has an invisible impact on brain development, reducing intellectual capacity at school and in working life, even amongst those with mild or moderate deficiency.
It has an invisible impact on brain development, reducing intellectual capacity at school and in working life, even among those with mild or moderate deficiency.
"That's the time when things are going wrong, prenatally," explains Bhattacharyya, who studies how abnormal brain development leads to intellectual disability in Down syndrome and fragile x syndrome.
The government's balance was framed as one between affordability and intellectual property rights, as well as international development and intellectual property rights.
