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SLIT1 is widely reported to be involved in brain development and axon guidance [25].
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Overlap between DCN and R7/8 axons can be seen at different times during brain development and in the adult brain.
Drosophila models show stronger phenotypes with defects in brain development, axon pathfinding, and effects on courtship-based learning and memory formation and circadian rhythms.
These include involvement in the developmental process, brain development, neuronal differentiation, axon guidance, and regulation of neurons in the developing neocortex.
Disruptions of neocortex development and axon guidance were proven to be pivotal in the pathophysiology of ASD [50 53].
Although the development and axon outgrowth of these motoneurons has been characterized, cues that determine whether axons will grow dorsally or ventrally have not been identified.
These data indicate that PNPLA6 plays a key role in normal neural development and axon maintenance.
Axon guidance was one of the top over-represented pathways, and is important for brain development, dopaminergic axonal maintenance, regeneration and target recognition.
EGR2 is involved in brain development (63– 65), myelination and routing of axons (66, 67).
Li et al. also found that messenger RNAs from many genes involved in postnatal brain development—affecting processes such as the growth of axons and dendrites and the formation of synapses exhibit defective alternative splicing in the mutant mice.
THE LEARNING BRAIN Memory and Brain Development in Children.
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