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Courchesne E, Chisum HJ, Townsend J, Cowles A, Covington J, Egaas B et al. Normal brain development and aging: quantitative analysis at in vivo MR imaging in healthy volunteers.
By measuring the molecular and metabolic changes that occur in the brain, this technique has provided valuable information on brain development and aging, Alzheimer disease, schizophrenia, autism, and stroke.
The role of DNA cytosine methylation, an epigenetic regulator of chromatin structure and function, during normal and pathological brain development and aging remains unclear.
To date, there are no comprehensive studies which have monitored methylation at multiple loci during the course of brain development and aging, or in chronic psychiatric disease.
Most of the cancer-related genes included in this study show aberrant methylation in various types of neoplasia, including CNS tumors (Table S1), and hence we were interested to monitor potential methylation changes within these genes during the course of normal brain development and aging.
This has been and will be a most important and valuable clinical research cohort to study and will help answer questions about vulnerability as well as resiliency in brain development and aging.
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UCHL1 is involved in brain development and age-related neurodegenerative pathologies such as Parkinson's disease [ 111].
In addition, our analysis showing the regulated expression of miR-101 in brain development and ageing and in a neurodegenerative process suggests important roles for this miRNA in nervous system physiology and pathology.
Their goal is to understand the way that the brain functions and regulates its blood flow, which can provide important clues to understanding early brain development, disease and aging.
Research topics include neural oscillations for auditory perception, auditory-motor coupling, brain plasticity in development and aging, recovery from stroke with music-supported therapy, and re-learning of speech and music after cochlear implantation.
The genes responsible for neuronal growth and synaptogenesis are expressed at their highest levels during early brain development and decline with age, but a stroke event re-initiates the increased expression of these genes for a limited period after stroke [ 21].
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