The EGFR family and its ligands are variably expressed from embryogenesis, throughout brain development, and into adulthood.
Thus, we decided to test the spatial expression of spatacsin during mouse brain development and in adulthood.
Alterations in network connectivity might ultimately be related to a deregulation of mTOR signalling in the PFC, occurring at a critical period in post-natal brain development and persisting into adulthood.
Studies have shown, for example, that infants and toddlers growing up in low-income communities are more likely to experience the kind of "toxic stress" (neglect, abuse, seeing violence in the home) that can hinder brain development and lead to mental illness in adulthood.
Neurotrophic factors may serve as therapeutic agents because they play key roles in coordination of brain development and maintenance of brain function in adulthood.
This likely means that in addition to failing to grow, they have delayed brain development and lower IQs, will be more susceptible to disease well into adulthood, and for females, their future children may be affected in the womb, even years after nutrition has been restored.
The neurodevelopmental hypothesis of schizophrenia suggests that the onset of abnormal brain development and neuropathology occurs perinatally, whereas symptoms of the disease appear in early adulthood [ 32].
When maternal care is modified by experimental manipulations, the effects on infant brain development and behavior occur across a broad range of measures and are detectable during adulthood.
1, 2 In this study, we focus on reelin, a glycoprotein, which plays an important role in early brain development and also extends its functionality in regulating the structural plasticity of neural networks in adulthood and aging.
