Sentence examples for brain depletion from inspiring English sources

To address this question, we carried out global NE brain depletion or local NE deafferentiation in the prelimbic cortex (PrL) area of the PFC in mice lacking the β2-subunit of nAChRs (β 2−/− mice) and C57BL/6 control mice.

Serotonergic mechanisms are thought to play an important role as brain serotonin depletion prevented the antinociceptive effect of acetaminophen.

Its capacity to detect brain cholinergic depletion has also been shown recently in rats [14], although no postmortem confirmation was provided in this study.

And finally, our group has developed the first high affinity, D3 selective PET ligand, [18F]Fluortriopride ([18F]FTP), which has demonstrated feasibility for imaging D3 receptors in non-human primate brain, following depletion of endogenous dopamine (Mach et al., 2011; Tu et al., 2011).

However, because ablation of peripheral macrophages does not impair VSV encephalitis or viral clearance from the brain but depletion of splenic marginal dendritic cells impairs this response and enhances morbidity/mortality [48], it is tempting to speculate that these dendritic cells may also be increased in EEPy as compared to IEPy animals.

It was confirmed by brain capillary depletion analysis [ 112].

Early studies in rats demonstrated that global brain serotonin depletion made them insensitive to punishment.

These findings clearly indicate that brain iron depletion may be one cause of abnormally low dopamine levels, which have a central role in the pathophysiology of RLS.

Activated vitamin D reduces iron-induced and zinc-induced oxidative injuries in rat brain through depletion of glutathione and subsequent generation of reactive oxygen and nitrogen inflammatory species.

Brain specific depletion of desat1, which encodes a desaturase enzyme involved in pheromone biosynthesis, was shown to alter pheromone production (Bousquet et al., 2012).

In each case neuropathologic examination of the brain revealed depletion of pigmented neurons in the substantia nigra but without Lewy bodies, the pathologic hallmark of PD.