In this work, we have improved the COMBINER method a computational framework for identifying gene expression modules that are activated in common across experimental conditions and applied it to blood and brain data from a mouse social defeat model.
Since a substantial amount of IMS research focuses on the rodent brain, our case studies use MALDI-TOF IMS data from mouse brain tissue as the empirical data source and the Allen Mouse Brain Atlas as the curated anatomical data source.
Data from mouse brain FDG PET with IFs determined with a coincidence counter on an arterio-venous shunt were analyzed with the two-tissue compartment model.
The study of Maertens used a series of statistical and biological methods and tools in the following way: starting point was a set of transcriptome data from mouse brain tissue, with four replicates each from day 0, day 1 and day 7 relative to MPTP dosing.
This suggests that, consistent with the above data from mouse and rat, Iγ_v6 is not a major brain variant.
Data from mouse studies and human channelopathies provide important insight into the potential role of Cav1.2 and Cav1.3 LTCCs in human brain disease.
However, paricalcitol, a vitamin D analogue, did not significantly enhance [I]hAβ 1-40) elimination from mouse brain (data not shown).
Finally, PrPres could not be detected on brain sections from mice inoculated with H-type isolates (data not shown), thus confirming the Western blot data.
However, none of the POMs were reactive with PrPSc from prion infected mouse brain (data not shown).
This non-invasive process allowed surgeons to remove brain tumors from mice with great accuracy.
