We demonstrated that bi-ligand liposomes accumulated in rat brain at significantly (p < 0.05) higher concentrations as compared to the single-ligand (transferrin) or plain liposomes.
For in total three cyclic peptides we show that administration of cyclic peptides resulted in up to tenfold higher peak concentrations in brain as compared to their linear equivalents which have partially been characterized before (Jiang et al., 2015; Leithold et al., 2016a).
THC-treated mice had significantly decreased brain concentrations compared with vehicle controls of risperidone (Figure 3a), 9-hydroxy risperidone (Figure 3b), and the total active drug moiety (the combined brain concentration of risperidone and 9-hydroxy risperidone) (Figure 3c), following risperidone challenge.
Two-way ANOVA indicated that THC-treated mice had significantly decreased brain concentrations compared with vehicle of risperidone (F 1, 26)=10, P<0.01), 9-hydroxy risperidone (F 1, 26)=19.1, P<0.001), and the total active drug moiety (F 1, 26)=17, P<0.0001).
PrPTSE was found in the left ventricle of the heart at a 10- to 100- fold lower concentration as compared to the brain, but not in skeletal muscle [27].
In the study of Jose et al., resveratrol-loaded SLN were equally effective as free resveratrol and SLN could remarkably increase the brain concentration of resveratrol as compared to free resveratrol.
This could be due to the limited strain applied to the system as well as the relatively low filament concentration as compared with ref. 20.
The use of 31 P-AC significantly increases brain activity as compared with NoBone-AC and overestimates brain activity as compared with CT-AC (p < 0.001).
By contrast, Zn concentrations in the liver and kidney were significantly increased, and minimally increased in the spleen and brain, as compared to the vehicle controls (Cho et al. 2013).
All minocycline concentrations were higher in wild type mice than in R6/2 mice (Table 2) We also tested two oral doses of minocycline based on Smith et al's study [26] in which higher concentrations of plasma and brain minocycline were achieved as compared to the daily i.p. injections of Chen et al's study [25].
