Sentence examples for brain concentration of the from inspiring English sources
total brain concentration of the drug.
If the VT of a labelled drug is not reduced following the administration of pharmacologically relevant dose of the same drug, the total brain concentration of the drug (CT) can be taken to measure the sum of the free and the non-specifically bound components.
In the rat pilocarpine model of epilepsy, increased brain concentration of the active metabolite of oxcarbazepine was observed following seizures together with inhibition of BBB efflux transport, but without changes in plasma concentrations.
For each of the conditions mentioned above, we then simulated the displacement of the tracers setoperone or altanserin by the appropriate functional brain concentration of the antipsychotic, given its known affinity for the human 5-HT2 A receptor.
We therefore determined the functional brain concentration of the antipsychotics for that particular clinical dose using the D2 receptor specific raclopride tracer imaging experiments reported for similar clinical doses in other patient groups in a primatized model of the striatal synapse [ 10].
These data indicate that the higher the brain concentration of RDX, the shorter the time interval between RDX administration and seizure onset.
To evaluate the potential pharmocokinetic interaction, total brain concentrations of the studied antidepressants were determined by HPLC method.
Fig. 1c also shows that self-administering 5- or 90-s cocaine injections under IntA would produce a similar spiking pattern in brain cocaine concentrations, and that there would be no large effect of cocaine infusion rate on peak brain concentrations of the drug (see also refs [8, 9, 14]).
Toxicokinetic data on blood and brain concentrations of the two marker compounds in the rat, together with in vitro partition coefficients were used to develop physiologically based pharmacokinetic (PBPK) models for TMB and NDEC.
