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In the case of prodrugs, once in the brain compartment, the active therapeutic agent is released.
Pharmacological distribution volume in second brain compartment.
Pharmacological distribution volume in first brain compartment.
A second (peripheral) brain compartment was evaluated for (R -11C]verapamil, wheR -11C]verapamil (R)-11C]verapamil concentration in the peripheral slowhereilibrating brain compartment (Equation 4).
SE was found to influence the pharmacological volume of distribution of the central brain compartment V br1.
Tariquidar treatment lead to an increase in V T-NLME, and pilocarpine-induced SE lead to increased (R -[11C]verapamil distR -[11C]verapamileripheral brain compartment.
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c, Quantification of the number of macrophages (CD11b+CD45high cells), CD4+ and CD8+ T cells recruited to the indicated brain compartments.
Here, we demonstrate that myogenic cell lines grafted into the ventricles of rat embryos showed widespread migration into several host brain compartments.
d, Relative expression of inflammatory cytokines (normalized to Actb) either in Tβ-syn cells isolated from the indicated brain compartments (left) or in brain tissues (right) assessed by quantitative PCR.
Quantification of Gd enhancement in the indicated brain compartments performed as in b. e i, Repeated Tβ-syn-cell-induced autoimmune inflammation induces long-term damage in the cortical grey matter.
Plots, quantification of TOVA cells (c) or TMBP cells (d) in the indicated brain compartments 3 days p.t. Rats were injected i.c.v. with the cognate antigen 12 h before analysis.
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