Sentence examples for brain compared to young from inspiring English sources

These results indicate that p52 replaces p50 in the DNA bound dimer in aged brain compared to young.

Microarray analysis showed co-expression of multiple Gene Ontology families in rhTFAM-treated aged brains compared to young brains.

NF-(B mediates its action by binding DNA, therefore to examine whether the increase in p52 is associated with a change in the composition of the DNA bound NF- B dimer, gel shift assay was used. As previously reported with other tissue [ 28- 30], a general increase in NF-(B DNA binding is evident in brains of old mice compared to young (Fig. Supplemental S3C).

Given that there are fMRI studies proposing older individuals recruit increasingly more bilaterally distributed brain regions compared to younger adults in response to the same task, [47] our finding of stable hemispheric asymmetry is somewhat unexpected (but see [48]).

In fact, while both the number of dot-like (aggregated) ref(2 p structures as determined by immunofluorescence and overall levels of ref(2 p as quantified by total pixel intensities increased in brains of aged (30 days) compared to young (10 days) control animals, this increase was largely abolished in the animals expressing the AcCoAS RNAi by appl-gal4.

Figure 2 shows that levels of expression of these mitobiogenesis genes were reduced 55.6-64.855.6-64.8% and 27.1-59.3% in heart compared to young CTL mice but were not reduced in skeletal muscle.

We found that Sirt3 expressionwas significantly reduced ~40% in old compared to young mouse brains.

Aging typically leads to a more than 100-fold reduction of neurogenesis rates in aged compared to young adult brains (Kuhn et al., 1996).

Furthermore, in crude extracts prepared from human brains, reduced activities for aged samples compared to young controls parallel the increases of CKb carbonylation [ 13].

As shown in Table 1, we found highly significant overlap among genes with >3-fold differential expression in aged mice treated with rhTFAM and 19 GO families differentially expressed in aged compared to young adult brains.

Interestingly, as with Nfkb1 +/+ tissue, an increase in p52 is also seen in aged compared to young Nfkb1 −/− brains (Fig. Supplemental S3B).