23 Taken together, these brain changes suggest that HTN is an underlying neuropathologic precursor to cognitive impairment and dementia.
Although influenza virus RNA has not been detected in the fetal brain, these changes suggest that fetal effects could be secondary to the maternal inflammatory response, rather than the result of a direct viral effect (22 ).
These changes suggest that these regions have reduced connections with other brain regions compared with normally sighted subjects.
These changes paralleled oscillations in Fabp7 mRNA throughout the brain suggesting that cell-coordinated signals likely control brain-wide Fabp7 mRNA expression.
Although animals seem to undergo brain changes that suggest a kind of addiction to sugar, that has yet to be clearly demonstrated in people.
For example, a Russian study, published in Human Physiology, discovered that children who listened to classical music for an hour a day over a six-month time period exhibited brain changes that suggested higher states of relaxation, even when the test subjects were not asked to pay attention to the music.
A study of asymptomatic individuals with HIV revealed decreased frontal grey matter volumes in the absence of other brain changes [ 38], suggesting that cortical atrophy begins in frontal areas.
In contrast, manipulations occurring on or after P7 do not cause similar long-term changes in the brain, suggesting that these later changes have little or no effect on the development of the cortex [38].
Although patients carrying MECP2 mutations as well as Mecp2 knockout mice display a normal brain cytoarchitecture without detectable loss of neurons [3,9], recent studies indicate that MeCP2 regulates the number and function of excitatory synapses in the brain [7], suggesting that changes in neuronal functions may represent the primary cause of the neurological phenotype in RTT.
In minipigs, however, diet-induced obesity resulted in a decrease in CBF in several of these brain regions, suggesting that the changes in CBF were the result of weight gain (31).
