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It has long been suspected that relapse in schizophrenia is associated with disease progression in so far as time to response is longer, negative and other symptoms persist, some patients become treatment refractory and neuroprogression in terms of structural brain changes may occur.
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As we age, natural changes may occur in our brains.
When we repeat a behavior, physiological changes may occur not only in the parts of the brain responsible for motor control but also in the parts that deal with more cognitive functions.
Such changes may occur later in development and involve cholinergic markers in other brain structures such as the striatum, with stable measurements observed in the hippocampus.
As the condition becomes chronic, painful osteoarthritic changes may occur.
Cutaneous and nail changes may occur in children receiving hydroxyurea.
These changes may occur early in treatment, preceding volume changes.
The team will follow the families to understand more about whether and how the effects last over the long-term; they'll also look at what brain changes may be occurring.
In the other half, the switch of control from left brain to right brain may occur because of chemical changes in fetal development.
These changes in brain states may occur as a result of repeated migraine attacks through maladaptive coping mechanisms [33].
We also plan to include functional magnetic resonance imaging scanning and gene analyses so as to examine possible changes in the brain that may occur due to CT, as well as identify any potential factors (eg, familiarity with computers) that may aid or hinder individuals in progressing and benefiting through late-life CT.
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