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Meta-analyses of longitudinal neuro-imaging studies have found evidence for spatial progression of structural brain changes in schizophrenia [ 96].
Our results identify the specific brain regions where possible associations between antipsychotic drug usage and structural brain changes in schizophrenia patients are more consistently reported.
Thus, by considering only studies with positive findings, ALE meta-analyses may carry a bias that overemphasizes the idea of structural brain changes in schizophrenia [ 71].
However, it seems clear that the idea of antipsychotics as potential agents contributing to the structural brain changes in schizophrenia should certainly be taken into account.
The results of multiple studies on the association between antipsychotic use and structural brain changes in schizophrenia have been assessed only in qualitative literature reviews to date.
While the progressive nature of structural brain changes in schizophrenia is not yet fully understood, they are thought to be in some degree due to a combination of abnormalities of synaptic plasticity, abnormal brain maturation and distinct environmental factors [ 37].
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Dr DeLisi was the first to conduct a longitudinal controlled MRI study that showed progressive brain change in schizophrenia and was a pioneer in developing an international collaboration for ascertainment of families with multiple members having schizophrenia to participate in molecular genetic studies.
In this study, we investigate whether there is overlap in the distribution of brain changes in First Episode Schizophrenia (FES) and Fronto-Temporal Lobar Degeneration (FTLD).
In this study, we identified overlap in the distribution of brain changes in First Episode Schizophrenia (FES) and Fronto-Temporal Lobar Degeneration (FTLD).
There is a significant overlap in the distribution of structural brain changes in First Episode Schizophrenia and Fronto-Temporal Lobar Degeneration.
The cytoarchitectural and morphological brain changes observed in schizophrenia are consistent with a pre/perinatal origin (Kovelman and Scheibel, 1984; Conrad et al, 1991; Jakob and Beckmann, 1986; Arnold et al, 1991).
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