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Our knowledge about the complex interplay between the various brain cells types (neuronal and non-neuronal) is still rudimentary.
Although the mechanisms remain complicated, together these studies suggest that HMGB1 TLR4 and perhaps RAGE signaling (which are found on multiple brain cells types) as well as neuronal glial neuroimmune signaling and microglial astrocyte activation all contribute to alcohol-induced brain damage.
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Skene, N. G. et al. Genetic identification of brain cell types underlying schizophrenia.
Mapping of disease risk variants to specific brain cell types in four brain diseases and seven non-brain diseases.
They will then use this information to catalog the newly-discovered brain cell types.
The patent covers an in vitro method of propagating neural stem cells from mammals so they mature into the three major brain cell types (called neurons, astrocytes and oligodendrocytes).
The term brain cancer refers to any of a variety of tumours affecting different brain cell types.
provided single-cell RNA-seq data for mouse brain cell types; J.B. and P.F.S. performed the single-cell gene expression analysis; and M.N., P.R.J., S.v.d.S., and D.P. wrote the paper.
Once generated, hiPSCs can be differentiated in principle to all specific brain cell types by providing a lineage-specific chemical environment and/or transient overexpression of transcription factors that determine the cell lineage.
(A) This figure shows the correlation strength (signed, negative log10 p-value: positive denotes a direct correlation) between 7 known gene markers of common brain cell types and the AD-related traits analyzed in this study.
By inventing a new computational pipeline called DAMAGES, Chaolin Zhang and Yufeng Shen showed that brain cell types on the left of the plot are more prone to have rare autism risk mutations than cell types at the right.
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