A new study has found that chronic stress can create many of the brain changes associated with mood disorders by blocking a gene called neuritin and that boosting the gene's activity can protect the brain from those disorders.
Nicotine permanently changes the chemistry of your brain by blocking dopamine receptors, leading to a lifelong addiction, even after quitting.
When investigators reduced norepinephrine activity in the brain by blocking certain norepinephrine receptors (i.e., postsynaptic alpha1-adrenergic receptors) with an antagonist, prazosin, alcohol consumption was reduced in both dependent rats (Walker et al. 2008) and alcohol-dependent humans (Simpson et al. 2009).
If it worked, the team reasoned, it would show that it was possible to treat migraines from outside the brain, by blocking CGRP only in the peripheral nervous system.
Although the mechanism of action of VPA is not fully understood, it may reduce neuronal activity in the human brain by blocking sodium and calcium channels and enhancing γ-aminobutyric acid (GABA) function by inhibiting GABA transaminase.
We found that this drug significantly suppressed the incidence of metastasis as well as growth of CSCs of 231BrM in the brain by blocking HES5 expression (Fig 6F; Supporting Information Fig S6G and H).
Interestingly, the expression of IL-10 is elevated during the course of most major diseases in the CNS including TLE and promotes survival of neurons and all glial cells in the brain by blocking the effects of proapoptotic cytokines and promoting expression of cell survival signals [ 32, 71].
Symptoms of Alzheimer disease can be reduced in some patients by the drug memantine, which decreases abnormal brain activity by blocking the binding of glutamate (an excitatory neurotransmitter) to certain receptors in the brain.
Symptoms of Alzheimer disease can be reduced in some patients by the drug memnatine, which decreases abnormal brain activity by blocking the binding of glutamate (an excitatory neurotransmitter) to certain receptors in the brain.
The alcohol-mediated inhibition of AQP4 could aggravate vasogenic brain edema by blocking fluid clearance following vasogenic brain edema that follows mechanical injury with DAI under acute alcohol intoxication.
