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This finding is potentially of significant importance since brain atrophy in human tauopathies correlates strongly with tau accumulation and dysfunction in the brain regions affected and is a parameter that can be quantitatively assessed in clinical trials.
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Perez-Miralles, F. et al. Clinical impact of early brain atrophy in clinically isolated syndromes.
Felbor, U. et al. Neuronal loss and brain atrophy in mice lacking cathepsins B and L.
However, little is known regarding brain atrophy in patients receiving peritoneal dialysis (PD).
Rojas, J. I., Patrucco, L., Miguez, J., Besada, C. & Cristiano, E. Brain atrophy in radiologically isolated syndromes.
Magnetic resonance imaging evidence of progression of subacute brain atrophy in moderate to severe traumatic brain injury.
Group 4 showed lesser degree of brain atrophy in cortex and striatum, when compared with other groups.
The relationship between WMHs and brain atrophy in CADASIL is not fully understood.
Brain atrophy in a patient affected by MPS VI; the patient started treatment with enzyme replacement therapy (ERT) in 2005.
Thus, the real importance of brain atrophy in the pathogenesis and clinical progression of CADASIL remains controversial.
One study found fish oil could prevent cognitive decline and brain atrophy in older adults.
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