These advanced MRI techniques have been used to detect occult vascular damage, brain blood flow changes, brain atrophy, and brain functional connection in the resting state.
The tau and p-tau proteins are associated with neurofibrillary tangles, which are more associated with synaptic dysfunction, brain atrophy, and cognitive and functional impairment than Aβ [ 8, 46, 47].
Aging is associated with cognitive decline, diminished brain function, regional brain atrophy, and disrupted structural and functional brain connectivity.
99, 100 However, data from controlled clinical studies suggest divalproex accelerated brain atrophy, and did not benefit patients with moderate AD in terms of neuropsychiatric symptoms, functional abilities, and cognition.
These decrements in cognitive functioning are associated with modest brain atrophy and vascular lesions on brain magnetic resonance imaging (6).
Brain MRI showed brain atrophy and old fine cerebral infarctions.
It further reduced brain swelling, neuroinflammation, neuronal loss, delayed brain atrophy and neurological deficits.
While unimodality analyses showed widespread brain atrophy and hypoperfusion in the patients, jICA further revealed two significant joint components of variations between atrophy and hypoperfusion across brain regions.
Brain atrophy and cognitive dysfunction are neurodegenerative features of Multiple Sclerosis (MS).
Brain imaging revealed generalised brain atrophy and bilateral mineralisation of the globus pallidus and substantia nigra.
