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For nearly all organs and time points, sufficient colonies (i.e. hundreds) grew, except for in the brain at later time points.
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Histopathologic evaluation of brains at later time points may be required to appreciate treatment group differences in inflammation.
The increase in cerebellar SUVmax values was less pronounced, possibly due to an already physiologically decreasing FDG uptake of brain tissue at later time points [ 25].
The normalized brain concentration at later times and the transfer rate (K1 or CLuptake, brain) were about half of those of a previous report using adolescent monkeys [[8]].
At 4 days p.i., MHC Class II was almost exclusively expressed in endothelial cells in the SIV-infected brain (Figure 6), whereas at later time points, it was expressed in endothelial cells but more prominently in macrophages.
This means that during the first 2 min after administration of 11C-dLop, efflux out of the brain is dominated by efflux transporters, while at later time points passive diffusion is more important.
The remaining brains were stored permanently in 10% formalin and additional brain regions were dissected and processed to paraffin blocks at later time points.
At later time points, ptpreb expression is fading, while ptprea remains strongly expressed in the entire brain (Fig. 13D).
There were no differences at later time points.
However, this difference disappeared at later time points.
This pattern persisted at later time points.
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