KO, KN and NA organized the brain archives including clinical information, selected appropriate cases, and performed neuropathological analyses of all cases used in this study.
This may be partly attributable to the fact that our brain tissue archive is principally based on the psychiatric hospital autopsies.
We used brain tissues, archived in our laboratory, from 7 patients with TPD, 22 with AD and 11 subjects without dementia or other neurological disease.
The concept of research on human samples has been pioneered by neuropathologists who had an interest in research and who started to archive brain specimens referred for diagnosis, such as the one developed by John Corsellis in 1950 [ 1].
Therefore, in the mid-20th century, the notion of brain banking to archive, collect, and use human brain samples became essential with the aim to facilitate access to the tissue, to simplify the administrative burden for the researcher, and to improve their quality for cutting-edge research on neurological diseases.
"It's going to be the Higgs boson of the brain, a Noah's archive of the mind," he says.
Permission to perform an autopsy and archive the brain and spinal cord for research purposes was obtained from the patients' relatives by the attending physician after death.
Our laboratory has developed an online interactive resource called PhenoGen (http://phenogen.ucdenver.edu) which provides an archive of brain and other organ gene expression data from a panel of 20 common inbred mouse strains, and three recombinant inbred (RI) panels (two mouse and one rat).
"What Works in Inpatient Traumatic Brain Injury Rehabilitation?," from Archives of Physical Medicine and Rehabilitation Finally, traumatic brain injury, or T.B.I., is becoming a topic of conversation.
In the present study, we isolated RNAs from archived FFPE brain specimens of postmortem cases of ALS and neurologically normal controls.
