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The relative contributions of the brain and the periphery that endow the Iceman with these capabilities is unknown.
To investigate this, we conducted multi-modal imaging assessments of the brain and the periphery using a combination of fMRI and PET/CT imaging.
First, we will briefly review the known functions and roles of aldosterone, and then consider its actions in both the brain and the periphery.
I will describe how both the brain and the periphery are susceptible to elevated CGRP and how CGRP appears to act by distinct mechanisms in these sites.
The brain primarily coordinates and processes higher-level functions (e.g. sensory processing, cognition, motor movements, etc)., while the spinal cord serves as a medium of communication between the brain and the periphery.
We measured insulin levels as well as insulin signaling in the brain and the periphery of young and aged animals.
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However, local inhibition is not the only major effect: before the CSP has time to start, pyramidal cells are activated and send their signals to neighboring and distant parts of the brain and towards the periphery.
These compounds act on α2-adrenoceptors and imidazoline I1 receptors in the brain and in the periphery (17).
Other examined variables in the brain and in the periphery included inflammatory cytokine levels, hippocampal gene signatures, and insulin signaling.
Optineurin is associated with some familial forms of amyotrophic lateral sclerosis and it is ubiquitously expressed both in the brain and in the periphery.
Nicergoline is a semisynthetic ergot derivative and has a selective alpha-1A adrenergic receptor blocking property and also other additional mechanisms of actions, both in the brain and in the periphery.
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