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In addition, oxidative stress has been associated with the aging of the normal brain and the development of late-onset neurodegenerative diseases.
Hence, BACE1 activity plausibly plays a rate-limiting role in the generation of potentially toxic Aβ within brain and the development of AD, thereby making it an interesting drug target.
The findings provide basic knowledge about the functional architecture of the brain and the development of uniquely human and specialised higher cognitive systems.
Thus, it is possible that both bacterial and host genetic factors are involved in infection of the brain and the development of meningitis.
Most animals survived infection with no signs of illness, despite virus invasion of the brain and the development of mild encephalitis.
Indeed, systemic administration of TNF- α has already been shown to have central effects as indicated by increased proinflammatory gene expression in the brain and the development of sickness [ 28, 29].
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The overall trend through time is clear: larger size, longer limbs, reduction of side toes, development of a longer snout and larger brain, and especially the development of higher-crowned cheek teeth for eating gritty grasses.
However, Sherwood says, "extraordinarily little data exists" on brain growth and the development of myelin in our closest genetic relatives, chimpanzees.
Recent studies also suggest that the interaction of alcohol with specific genes involved in brain development and the development of facial features may affect the FASD phenotype.
Steeg discussed her current work in understanding brain metastasis and the development of potential targeted therapies for this devastating condition [ 6, 7].
Furthermore, administration of an IL-17 blocking antibody in mice immunized with a myelin antigen prevents chemokine expression in the brain and the subsequent development of EAE [ 44].
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