Investigation of Prp2 depleted embryos revealed high mortality and apoptosis at 24 hours post fertilization (hpf) as well as impaired brain and neuronal development.
Genes in the caspase-dependent apoptosis pathway, of which caspase-7 is a part, are critical in mammalian brain and neuronal development.
Determining the unique aspects of brain and neuronal development and differentiation in higher organisms will be key to uncovering the processes leading to these structural and functional differences.
ICAM-5 regulates both immune response and neuronal development in the brain (Gahmberg et al., 2008; Tian et al., 2008).
Estrogens have multiple effects in the brain, including neuronal development and maturation [1], synaptic plasticity [2] and excitability [3], neuroprotection and survival [4], and neurotransmitter and neuropeptide synthesis [5].
A recently identified class of master regulatory molecules, known as microRNAs (miRNAs), have the potential to assist in the countless regulatory mechanisms that occur in the brain during neuronal development and function.
DOI: http://dx.doi.org/10.7554/eLife.00178.002 RNA binding proteins (RNABPs) play critical roles in the brain to regulate neuronal development and activity, as underscored by the finding that dysregulation of RNABP function underlies a growing list of neurological disorders (Licatalosi and Darnell, 2006; Cooper et al., 2009; Poulos et al., 2011).
A young (P15) recipient brain favored neuronal development of grafted cells, as the BrdU+/NeuN+ cells constituted 84% at P15, 66% at P21 (P<0.05) and 38% at P56 (P<0.001).
A young recipient brain favored neuronal development of grafted cells, whereas the older recipient brains displayed an increasing number of cells developing into astrocytes or unidentified cells.
They are involved in several aspects of brain activity such as neuronal development and neuroplasticity during learning and memory formation1.
Meng H, Smith SD, Hager K, Held M, Liu J, Olson RK, Pennington BF, DeFries JC, Gelernter J, O'Reilly-Pol T, Somlo S, Skudlarski P, Shaywitz SE, Shaywitz BA, Marchione K, Wang Y, Paramasivam M, LoTurco JJ, Page GP, Gruen JR. (2005) DCDC2 is associated with reading disability and modulates neuronal development in the brain.
