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Researchers had previously uncovered 200 of these regions, some of which are linked to brain and limb development.
Sp8 may play a role in chondrogenic/osteoblastic differentiation in addition to its role in brain and limb development.
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One possible underlying cause for a more relaxed purifying selection on heart enhancer is that during mouse embryogenesis, heart development begins and finishes earlier than brain and limb developments.
The significant effects in multiple organs and regions and in total scores (Table 1) demonstrated that alcohol treatment resulted in retardation of the overall growth and interfered with development of several specific structures, including brain, heart, and limb development, in this embryonic culture model.
Dkk1 is required for embryonic head and limb development.
The fibroblast growth factors (FGFs) and their receptors (FGFRs) play an important role in a wide range of biological functions, controlling developmental events such as brain patterning, morphogenesis and limb development [ 4, 5] with multiple physiological functions in the adult including angiogenesis, wound repair and endocrine functions [ 6].
Nine patients were studied for manual preference and limb development.
During fin and limb development, Shh is required to pattern the anteroposterior axis of appendages.
We also did not detect any developmental delay in apparently unaffected diabetes-exposed embryos; their morphological appearance, i.e. features of brain development, limb development, and somite numbers were commensurate with developmental age (Kruger et al., manuscript in preparation).
There are important differences between mouse and chicken limb development as there are differences between forelimb and hindlimb development.
It was pitifully obvious that Parkinson's disease was severely debilitating his brain and limbs.
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