Genomic imprinting on the X chromosome: implications for brain and behavioral phenotypes.
It is, however, extremely difficult to assemble sufficiently large samples of human brains to enable well-powered eQTL mapping studies relevant to brain and behavioral phenotypes.
Ts65Dn is the most widely studied mouse model and recapitulates some aspects of brain morphology and behavioral phenotypes observed in people with DS (Reeves et al., 1995).
Bearden and colleagues [ 17] have begun to address this issue by relating regional brain abnormalities with cognitive ability and behavioral phenotype in a sample of 13 children with DS22q11.2.
Hanson E, Bernier R, Porche K, Jackson FI, Goin-Kochel RP, Snyder LG et al. The cognitive and behavioral phenotype of the 16p11.2 deletion in a clinically ascertained population.
Therefore, our studies contribute to a greater understanding of prostaglandin-dependent regulation of glutamatergic signaling, as well as implicating the PKA/AKAP postsynaptic signaling complex as a regulator of AMPA receptor dynamics, the formation and stabilization of dendritic spines, and eventually a sexually differentiated brain and masculine behavioral phenotype.
Complex demographic and behavioral phenotypes can arise from coordinated interactions among brain systems.
Was the recent evolution of brain development and intelligence in humans driven by selection on mothers for cognitive, affective, and behavioral phenotypes that enhance early-childhood survival?
The cat (Felis silvestris catus) shows significant variation in pelage, morphological, and behavioral phenotypes amongst its over 40 domesticated breeds.
The results presented herein demonstrate that reduction in GluN2C-containing NMDARs leads to cortical excitatory-inhibitory imbalance and abnormal neuronal oscillations and behavioral phenotypes reminiscent of neurodevelopmental disorders.
