These findings can serve as a step toward the understanding of the way the brain functions and evolves with age which is a significant element in the design of assistive environments.
Kawas focuses on the aging brain, which is a growth area, partly owing to demographics: In much of the world today, she says, people over 90 comprise the fastest-growing segment of the population.
However, an important issue is to understand the transition from physiological to pathological brain aging which leads to neurodegenerative disorders.
Gliosis is a widespread phenomenon in the aging mammalian brain, which is easily detected as up-regulation of GFAP (Riddle, 2007; Park et al., 2009).
Since AD develops in the aging human brain, which is subject to effects of sex hormone depletion in both sexes, gonadectomy in mouse models of AD recapitulates a critical aspect of human reproductive aging in males and females.
It is tempting to speculate that the common haplotype might be a marker for the increased substitutions in brain mtDNA which is associated with younger ages of morbidity in both psychiatric disorder and control groups.
These mice exhibit GluCer accumulation and α-syn build-up in the brain, which is associated with age-dependent neurological deficits (Xu et al., 2011).
And in this day and age where it's all about brain power, the nation with the best brain power wins, which is why education is so important.
There's also the brain, which isn't immune to aging either.
All of these data indicate that Ano3 is important in the mammalian brain, which is also suggested from its increasing gene expression pattern at different stages of brain development and brain-specific expression at adult age (data not shown).
