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OS, determined by increased ROS production and decreased expression of CuZn-SOD and Mn-SOD, was induced in the mouse brain after administration of TiO2, ZnO, or Al2O3 NPs [76].
The increased uptake of (R -11C]verapamil into the bR -11C]verapamilintoathen of tariquidar was assumed to brainther due to increaftertradministration-11C]verapamil intoftariquidar(i.e., increased Q in, Equation 2) or decreased transport of (R)-11C]verapamil out of the brain (i.e., decreased Q out, Equation 3) [25].
In contrast, the same study also looked at dopamine levels in the rat brain after administration of bupropion via intraperitoneal injection and did see an increase, which could have been related to species differences.
Our previous observation that AM404 is produced mainly in the brain after administration of acetaminophen in vivo [12] prompted us to study its effect following intracerebroventricular injection in the mouse formalin test.
These observations support results of our previous studies where we demonstrated no inflammatory response in the brain after administration of the same doses of vector via the same route of administration in both species (8, 9).
The only tissue that accumulated higher porphyrin levels from He-ALA (seven times more than ALA) was the brain, and this correlated well with a rapid increase in ALA/He-ALA content in brain after administration of He-ALA.
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The distribution of radioactivity in the brain regions after administration of the radioligand was consistent with the distribution of α7 nAChRs in the monkey brain [25] [27].
Recent studies examining the four TSPO radioligands of interest presented two scenarios when radiometabolites were a relatively high percentage of brain radioactivity: (1) after administration of XBD173, which blocked uptake of parent radioligand; and (2) in LABs, where low uptake of parent radioligand was caused by the low affinity of TSPO in this genotype.
We found no infarctions, dilatation of the cerebral ventricles, or morphological signs of cell death in any of the brain regions examined after administration of Pam3CSK4 or LPS.
For planning CT, 3 mm scans of the brain were obtained after administration of an i. v. contrast agent.
Data were taken from [11 C]N-methyl-SSR504734 studies in the rhesus monkey brain at baseline and after administration of SSR504734 at doses of 1.5 mg/kg in rhesus monkey 1 (A) and 4.5 mg/kg in rhesus monkey 2 (B).
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