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A recent functional magnetic resonance imaging study reported that the selective CB2 agonist AM1241 did not alter brain activation in rats, whereas a CB1/CB2 receptor agonist produced dose-related changes in brain activity (Chin et al., 2008).
The 60 mmHg CRD pressure also induced more total brain activation in rats with CORT implants (Figure 4B).
Our results showed that there are significant differences in brain activation in rats in response to modulation of the amygdala via elevated levels of CORT.
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We aimed to investigate the effect of the increase of tidal volume (Vt) on brain activation in a rat model.
Recent studies claimed to have performed functional brain activation in unrestrained conscious rats in response to CRD [47], however the results from these studies must be treated with caution.
Our laboratory took the approach of 'following the money', that is, the fate of lactate and glucose label during brain activation in normal conscious rats.
A significant advance made in the current study was the enhanced brain activation in response to CRD in rats with CORT-containing micropellets placed stereotaxically on the dorsal margin of the amygdala.
Analysis of the imaging data demonstrated greater overall brain activation in response to CRD in rats with CORT implants compared to CHOL controls.
In view of our initial observation of a greater increase in total brain activation in response to CRD in rats with elevated amygdala CORT for 7 days, we attempted to systematically examine specific brain nuclei that showed activation in CORT-treated rats but not in CHOL-implanted rats to gain a more complete picture of the central nuclei activated by CRD in the 2 groups.
Specifically we investigated brain activation in response to CRD between rats with bilateral amygdala implants of CORT and age and weight-matched CHOL control rats.
In the current study we investigated total brain activation in response to 40 and 60 mmHg of CRD in anesthetized rats with bilateral implants of CORT placed stereotaxically on the dorsal margin of the amygdala (Figure 2).
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com