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The post-mortem report highlighted that the fetuses had bilateral perisylvian PMG with other brain abnormalities such as cerebellar hypoplasia and abnormal olivary and dentate nucleus.
Infants with congenital cytomegalovirus infection (CCMVI) may develop brain abnormalities such as ventricular dilatation, which may potentially associate with sensorineural hearing loss.
However, young children with developmental disorders may not be able to express discomfort associated with brain abnormalities, such as a Chiari I malformation.
Brain images provide signals of brain anatomy and can be useful in diagnosis of numerous brain abnormalities such as malignant glioma [1].
Subtle brain abnormalities such as broadened lateral ventricles were seen on MRI in some patients.
Further research into this potential link between intracranial vascular anomalies and brain abnormalities, such as with noninvasive MR angiography and perfusion MR imaging, may be of value.
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Two years ago, you underwent brain surgery, for a structural abnormality.
The Zika-mediated brain developmental defects identified by the Columbia team are also consistent with other forms of brain abnormality, such as lissencephaly (smooth brain), which have been observed in Zika-infected babies.
Some patients have brain imaging abnormalities, such as focal infarction, brain malformations and periventricular leukomalacia; however, not all children with cerebral palsy have abnormal brain imaging and determining the aetiology in such cases is particularly challenging (O'Shea, 2008; Reid et al., 2013).
Rarely do these patients have solely a raised intracranial pressure without, e.g., traumatic injuries to the brain or developmental abnormalities such as neonatal hydrocephalus.
And, they hope to discover how and where in the brain Ptchd1 mutations produce other abnormalities, such as aggression.
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