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The observations suggest some element of neurodegenerative disease and brain abnormalities may be induced through an epigenetic transgenerational mechanism.
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Background: Previous reports indicate that brain structural abnormalities may be progressive in some patients with schizophrenia.
Alternatively, brain tissue abnormalities may be related to a deficiency in ATP7A mitochondrial copper-containing enzyme [9] with consequent energy failure.
Specific language abnormalities may be associated with pathology in Wernicke's area or Broca's area of the brain.
A generalized lymphadenitis and gait abnormalities may be detected.
Fetal heart rate abnormalities may be encountered.
Brain abnormalities may also be functional, sometimes involving remote structures connected to the area of primary damage.
In addition, abnormalities in glucose metabolism and insulin levels in the brain itself may be harmful.
Because abnormalities in the brain dopamine system may be closely related to the pathology of tic disorders [ 15], we hypothesized that aripiprazole may have therapeutic effects on tic manifestations.
Magnetic resonance angiography of the brain may be useful to detect vascular abnormalities, with venography if venous sinus thrombosis is suspected.
The brain may be it.
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