Sentence examples for bp in the proximal from inspiring English sources

Furthermore, PTH directly activated Osx gene transcription in cultured osteoblast-like cells, a response that required an ATF4 response element located between −201 and −194 bp in the proximal mouse Osx promoter.

In contrast, our study indicates that 3 CpG sites (−95, −49, and −8 bp) in the proximal promoter are also important for full COL9A1 promoter activity.

The SQL code used to construct the table is provided in Additional file 2. Using the functionality of the 'GenomicRanges' R library, we calculated from all STRs in the genome the subsets that are located within exons, introns or 5'-UTRs and those STRs located upstream (−2,000 to −1 bp), in the proximal promoter (−250 to +250 bp) or regulatory region (−2,000 to +1,000 bp), relative to the TSS.

These repeats (hatched boxes in Figure 2A) are 5248 bp in length; the proximal copy is 4555 bp from the Ac element while the distal copy is 2934 bp from fAc.

A greater number of indels per bp sequenced was observed in the proximal promoters (1/1220) than in the 5' flanking regions (1/1885 bp).

The real breakpoints were distant in average of 190 bp for the proximal breakpoint (SD=242 bp) and 267 bp for the distal breakpoint (SD=275 bp).

The genes closest to the peak based on NCBI Map Viewer are CDYL2 between 7 681 404 and 7 695 761 bp at the proximal end and, in addition to a 5S ribosomal RNA gene (between 9 222 444 and 9 222 549 bp), two genes near the distal end: CLEC3A between 9 640 139 and 9 647 945 bp and WWOX between 9 684 708 and 9 744 573 bp.

These results indicate that expression of the EgCCR and EgCAD2 genes is under the control of a promoter region (50 bp in EgCCR and 216 bp in EgCAD2) proximal to the transcription start site.

Homma et al. examined the methylation status of multiple regions of RUNX3 promoter CpG island (3478 bp) within the proximal promoter (No. 1 10) in gastric cancers and found that methylation at the region spanning the transcription start site (No. 5 8) is critical for loss of the RUNX3 expression (Figure 3B) [15].

As a starting point for comparisons among the three classes of promoters, we analyzed the distribution of the four nucleotides in each class by calculating the mean frequency of each nucleotide in a 10 bp sliding window across the TSS region, ranging from -500 bp (outside the proximal and core promoter regions) to +100 bp (downstream of the core promoter).

On the basis of sequencing data we selected a region between -437 to −270 bp relative to exon 1 of the PLA2R1 gene (black line in Figure 2B) which covers the 5'-CpG sites 6 14 (according to our nomenclature; -415 bp to −298 bp from exon 1) and localizes in the proximal promoter of PLA2R1.