Sentence examples for box at the root from inspiring English sources
To accurately assess convergent cis-regulatory conversions without the effects of sequence conservation, genes inferred to contain both a GA box and a GC box at the root of mammals were discarded.
Because these genes do not contain a GC box at the root of mammals, this correlation cannot be explained by conservation, and therefore these genes represent convergent binding site conversions occurring in eutherian mammals independently of birds.
No such pattern was found in genes containing only a GC box at the root of mammals, supporting the functional role of the ancestral GA box motifs in the common mammalian ancestor.
Although it is common to observe GA and GC boxes in the same promoter, at least 826 of these genes did not originally contain a GC box at the root of mammals, providing a lower-bound estimate of the number of ancestral SP1 target genes gaining a GC box along the human lineage.
That is, genes that have a GA box in the common mammalian ancestor and a GC box in humans tend to contain a GC box in birds significantly more often than expected by chance, even when discarding genes containing a GC box at the root of mammals (table 1).
Convergent SP1 binding site conversions in human and birds (table 1) were assessed according to the amount of overlap in ancestral GA box- and GC box-containing genes at the root of mammals.
Ancestral reconstruction according to this framework showed that exactly 1,800 genes inferred to contain a GA box in the common mammalian ancestor (the preferred binding motif at the root of mammals) now contain a GC box in humans.
