d Screening was defined as no history of gastrointestinal conditions and no large bowel symptoms in the past 6 months.
b Screening was defined as no history of gastrointestinal conditions and no large bowel symptoms in the past 6 months.
Also, participants aged over 60 years are required to have undergone a consultant review to exclude other serious causes of their bowel symptoms in the past 2 years, because colorectal cancer is more common in the those aged over 60 years, and guidelines recommend that changes in bowel habit in this group require hospital tests beyond the scope of this trial.
Participants aged over 60 years are required to have undergone a consultant review to exclude other serious causes of their bowel symptoms in the last 2 years, because colorectal cancer is more common in those aged over 60 years and guidelines recommend that changes in bowel habit in this group require hospital tests beyond the scope of this trial.
Participants aged over 60 years must have had a consultant review to exclude other serious causes of their bowel symptoms in the past 2 years, because colorectal cancer is more common in those over 60 years of age and guidelines recommend that changes in bowel habit in this group require hospital tests beyond the scope of this trial.
In conclusion, linaclotide significantly improved abdominal and bowel symptoms in this phase 3 trial (12-week treatment period+4-week RW period).
Neither study identified significant improvements in chronic bowel symptoms in patients randomised to the intervention.
Bowel symptoms in women with OASIS vary from 7.6%to61%1% depending on the severity of symptoms, parity and type of injury [ 10- 14].
Although gastrointestinal side-effects following pelvic radiation therapy are well documented, the occurrence and specificity of anal sphincter and bowel symptoms in long-term survivors have been less well studied (Andreyev, 2005; Putta and Andreyev, 2005).
To assess long-term bowel symptoms in women who underwent segmental bowel resection for deep-infiltrating endometriosis (DIE) compared with women who underwent resection of severe endometriosis without bowel resection.
