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Where exactly is the boundary of harm drawn?
However, trial sequential analysis with data of moderate or high GRADE quality of evidence (table 5) showed that for further studies to eventually show human albumin to be harmful the cumulative z score would have to cross the futility boundary and then the conventional boundary of harm before touching the corrected monitoring boundary of harm (figs 4 and 6).
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This was not about crossing the boundaries of harm and offence with viewers - this was simply a matter of the limits of acceptable conduct at work.
We did this for outcomes that showed significance in the cumulative meta-analysis, calculating heterogeneity adjusted required information sizes and applying trial sequential monitoring boundaries of benefit, harm, and futility.
The cumulative z curve touched the conventional boundary for harm but did not cross the trial sequential monitoring boundary for harm (trial sequential analysis adjusted 95% confidence interval of trials with low risk of bias 0.95 to 1.29) (fig 3).
The cumulative Z curve crossed the trial sequential monitoring boundary for harm, indicating that sufficient evidence exists for a 30% increase in relative risk of severe hypoglycaemia when intensive glycaemic control is targeted (fig 14).
However, the boundaries are not always clearly defined and in some cases behaviours that usually fall outside the boundaries of self-harm may indeed represent self-harm if performed with explicit intent to cause tissue damage.
"Vulgar and offensive language can cause real harm, crosses the boundary of appropriate conduct and even disrupts the entire work force," the policy states.
"Evidence of harm"?
Little chance of harm there.
Out of danger, out of harm.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com