The nanoparticle, which specifically targets tumor cells, might help surgeons better pinpoint the boundaries of brain tumors.
Standard histological procedures such as a Nissl stain are traditionally used to define boundaries of brain nuclei (e.g., [44], [48]).
The structure must be virtual in that it spans across the physical boundaries of brain, body, and environment.
The boundaries of brain regions were defined by reference to landmarks described by Paxinos and Franklin (Paxinos and Franklin, 2001).
To avoid this, we draw an ROI that encloses the tumor and some normal tissue and shrink the ROI through the normal brain tissue to the boundary of abnormal brain tissue.
In this approach, rather than modeling the changes in oxy- and deoxy-hemoglobin over the three-dimensional volume of the brain, we instead modeled the values at the two-dimensional surface boundary of the brain cortex.
Delineation has been found to agree with the operators' visual inspection most of the time except in some cases when the tumor is close to the boundary of the brain.
The radii of the outer boundary of the brain, skull and scalp compartments were set to 8, 8.5 and 9.2 cm, respectively.
This is not a substantial issue for linear normalization, which is mostly driven by a large contrast change at the outside boundary of the brain, but the blurred internal structures could easily confuse high-dimensional non-linear registration [21].
The superior (SFG) and middle frontal gyri (MFG) ROIs were placed halfway between the precentral sulcus and anterior boundary of the brain, on the most inferior slice where both gyri were visible as separate structures.
