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In the intent-to-treat analysis with 57 in each group, the upper 97.5% confidence boundary for the difference between the 80.7% (46 of 57) non-failures in the 5 days on/2 days off, and the 70.2% (40 of 57) non-failures in the continuously treated arm was 5.4% which is again well within the preset non-inferiority margin of 15%.
The upper 97.5% confidence boundary for the difference between the percent of non-failures in the 5 days on/2 days off (88.5% non-failure) arm compared to continuous treatment (78.4% non failure) was 4.8% which is well within the preset non-inferiority margin of 15%.
The upper 97.5% confidence boundary for the difference between the percent of non-failures in the 5 days on/2 days off arm (88.5% non-failure) compared to continuous treatment (78.4% non failure) was 4.8% which is well within the preset non-inferiority margin of 15%.
In the modified intent-to-treat analysis which designated the 5 in each group who discontinued treatment as failures, the upper 97.5% confidence boundary for the difference between the percent of non-failures in the 5 days on/2 days off, 80.7% (46 of 57), and that in the continuously treated, 71.4% (40 of 56) was 6.6% which is within the preset non-inferiority margin of 15%.
Noninferiority of biosimilar versus the reference was demonstrated: DSN (days) in cycle 1 was 1.17 ± 1.11 (biosimilar, N = 101) and 1.20 ± 1.02 (reference, N = 103), 97.5% confidence interval lower boundary for the difference was −0.26 days (above the predefined limit of −1 day).
Similar(55)
Considerable differences are found in the frequencies of vibration between the cases of "the same" and "different" boundary conditions; the differences are greater for the simply supported (S2) and clamped (C2) boundary conditions.
19 20 The fact that very similar results were observed in the PP and ITT populations, and that the lower boundaries of the 95% CI for the difference between OD and TID were −3.5% (PP) and −5.0% (ITT), indicated that the conclusion of non-inferiority of 3 g OD vs 1 g TID is based on robust data.
Likewise, there were no differences in the phoneme boundary for the /k/-/g/ continuum.
To minimize the effect of boundary conditions (i.e. to correct for the differences in the initial, nonlinear portions of the load displacement curves due to sample variables such as cartilage thickness, etc)., the slope of the linear part of the resulting 'maximum load-displacement' curve was computed and the residual displacement subtracted from the measured displacement.
In this paper we discuss the derivation and use of local pressure boundary conditions for finite difference schemes for the unsteady incompressible Navier Stokes equations in the velocity pressure formulation.
In this paper we discuss the derivation and use of local pressure boundary conditions for finite difference schemes for the unsteady incompressible Navier-Stokes equations in the velocity-pressure formulation.
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