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Applying the asymptotic bound with the small number of time steps resulted in some rather large bounds (≥ 1).
The 1.9 Å resolution structure of the motor domain of KSP, bound with the small molecule monastrol and Mg2+·ADP, reveals that monastrol confers inhibition by "induced-fitting" onto the protein some 12 Å away from the catalytic center of the enzyme, resulting in the creation of a previously non-existing binding pocket.
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This problem is well-studied and algorithms exist that match the lower bound with a small gap of logd asymptotically.
At the combined action of HL1 or HL2 with C60 fullerene, the C60 + HL2 structure formed the stable complex with DNA when bound with a small groove and at intercalation into it, while the C60 + HL1 structure formed the stable complex with DNA only in one case when binding with a large groove.
It is shown that HL2 forms the stable complexes with DNA only when bound with a small groove (Fig. 5a).
The chemical compounds formed the stable complexes with DNA: HL1 when binding with a great groove and at intercalation into a small groove, while HL2 only when bound with a small groove.
It is highly protein bound with a small volume of distribution and a nine-hour half-life.
This protease-inhibitor binding paradigm is observed at high resolution in a large set of crystal structures of trypsin, thrombin, and urokinase-type plasminogen activator (uPA) bound with a series of small molecule inhibitors (2- 2-phenol)indoles and 2- 2-phenol)benzimidazoles).
Chunky bracelets are made from strips of paper bound with elastic string; hundreds of small circles form cordlike necklaces reminiscent of African beads; rolled paper tipped with ink create chili-shaped beads.
Small hard-covered volumes, bound with thread and taped up the side, most of them from an old French stationer, their plasticized glossy lapis blue or turquoise covers shrank and shriveled.
Concrete/brick is a composite aggregate material (small rocks bound with cement) for concrete, and minerals and stone bound by heat for brick.
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