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A closely related antibody from the same donor did yield crystals when bound with the same HA, giving us an independent validation of the cryoEM results.The two structures also augment our understanding of receptor-binding site recognition by antibodies that neutralize a wide range of influenza-virus variants.
For the second case study, we measure the throughput bound with the same network configuration as the first case but with three different BT distribution patterns: random distribution, regular distribution, and clustered distribution.
Apply Lemma 3 to Theorem 14. (i) Note that as n → ∞, K + ( n ) converges weakly to H+, the Fréchet Hoeffding upper bound with the same marginals F and G, and that (F- 1(Z), G- 1(Z)) ∼ H+.
However, combined with the comparable high correlation coefficients between the PharmDock predicted binding energies and the experimentally measured binding affinities, this result suggests that a good prediction in the overall correlation does not guarantee a good ranking power for the ligands bound with the same protein.
In an ironic twist, the book itself is bound with the same material that's used to upholster Berlin's U-Bahn train seats because its iconic "puzzle print" is said to work like urban camouflage and deter tags.
Regardless of whether monosites or heterosites are used, both NHR bound with the same relative degree to each binding site (Table S4 .What discrepancies were attributable to a small number of low order binding sites of approximately 1.5 2 fold enrichment where occupancy of the heterodimer partner could not be detected.
Similar(51)
Monoclonal antibodies are structurally identical immunoglobulin molecules with identical epitope-specificity (all of them bind with the same epitope with same affinity) as against their polyclonal counterparts which have varying affinities for the same epitope.
In this case, similar toxicologic end points means chemicals that act by the same mechanism (e.g., chemicals bind with the same biologic receptor) or, if interpreted more broadly, damage the same target organ (Hertzberg and Teuschler 2002).
2D3 and 2D11 bound with essentially the same affinity to all domain-deletion mutants tested, indicating that their epitopes are in the Cat/Dis domain.
DB2285, the azabenzimidazole substituted analogue of DB1476, gave a 175-fold reduction in binding affinity to AAATTT (KD = 70 nM) relative to DB1476, and it binds with almost the same affinity with mixed sequences that have a G·C bp (AAA GTTT, KD = 63 nM).
The rPfRH240 recombinant protein also bound erythrocytes with the same specificity as the native 220 kDa PfRH2a/b protein (Figure 3B) in that it bound neuraminidase treated and trypsin treated erythrocytes but not chymotrypsin treated erythrocytes.
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bound with the α-helical
bound with the semiclassical
bound with the explicit
bound with the small
bound with the first
bound with the anti-PAD2
bound with the perfect
bound with the 3C-like
bound with the repressive
bound with the historical
bound with the underlying
bound with the inner
bound with the heady
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Justyna Jupowicz-Kozak
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