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Within the α2-adrenoceptors, these analogs bound with higher affinity at the α2A- and α2C-subtypes as compared to the α2B-subtype.
The YSX monobody bound with higher affinity, a slower off rate and a more favorable enthalpic contribution than the YS monobody.
The designed PNA probe (CJE195) bound with higher affinity to a previously reported low affinity site on the 16S rRNA than the corresponding DNA probe.
They demonstrated that CTLA-4, a homologue of CD28, bound with higher affinity (at least 10-fold) to both B7-1 and B7-2 [37] and inhibited CD4+ T-cell activation.
Results from DNaseI footprinting, thermal denaturation, circular dichroism, surface plasmon resonance and isothermal titration microcalorimetry studies demonstrated that both H-pin polyamides bound with higher affinity than their respective monomers.
Five of the 15 nonsteroid lipids in Table 3 were apparently bound with higher affinity by OxP-11D and ten were bound more effectively by D-4F.
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The labeled belatacept bound with high affinity to Raji cells.
UFP-502 bound with high affinity (pKi 9.43) to recombinant DOP receptors displaying moderate selectivity over MOP and KOP.
IGF-I bound with high affinity to recombinant IGFBP-3 and IGFBP-4 with KDs of <0.25 nmol.
In flow cytometric studies, E4G10 bound with high affinity to H5V cells (Fig 1A).
Likewise, JEG-3 cells exogenously expressing proteinase-dead ADAMTS-12 or LacZ bound with high affinity to their own ECMs.
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